Tower of Saviors takes place in a fantasy world where players assume the role of "Summoners" and collect various monster cards with various mythological backgrounds and rarities as the player moved on.According to the game's story, in ancient times, Humankind built a tower and named it the Enochian Tower. It was used to reach the heavens and learn the ways of the Gods. Once It was built, Demons in both Hell and Earth tried to use it as a gateway to enter and destroy the world of the Gods. A bloody war started between the Gods, the Demons and mankind within the walls of the Enochian Tower. Just when the Demons were about to succeed in their plan, The Gods used the last of their strength to break off the tip of the tower and placed seals on the tower and sealed the Demons within. Thousands of years later, The humans were still caught in the seemingly endless war with the remaining Demons in the tower. The only hope lies on Summoners to unleash the Seals within the Enochian Tower and seek help from the Gods.

There are two types of main currencies in the game: Coins and Diamonds. Coins can be collected from battles and through discomposing cards, while diamonds are obtained from completing a set of stages in-game. Coins are used for levelling up and evolving cards as well as trading cards and unlocking old stages. Diamonds are used for reviving a battle if the player was killed, refilling energy, increasing storage space and drawing rare cards from the "diamond seal" (five diamonds each draw).